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Article

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications

27 Aug 2019

Abstract excerpt

Growth factor independence 1 (GFI1) is known as a DNA binding zinc finger protein which can mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its target genes. GFI1 plays important roles in hematopoiesis, in particular in regulating the function of hematopoietic stem- and precursor cells and the differentiation along myeloid and lymphoid lineages. In recent years, a number of...

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PMID: 31508375
DOI: 10.3389/fonc.2019.00824

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