Article
Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.
EMBO reports - 1 Mar 2006
Fiolka Katharina, Hertzano Ronna, Vassen Lothar, Zeng Hui, Hermesh Orit, Avraham Karen B, Dührsen Ulrich, Möröy Tarik
Abstract excerpt
Gfi1 is a transcriptional repressor essential for haematopoiesis and inner ear development. It shares with its paralogue Gfi1b an amino-terminal SNAG repressor domain and six carboxy-terminal zinc-finger motifs, but differs from Gfi1b in sequences separating these domains. Here, we describe two knock-in mouse models, in which the N-terminal SNAG repressor domain was mutated or in which the Gfi1 coding region was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.