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Article

Gfi1–cells and circuits: unraveling transcriptional networks of development and disease

22 Jun 2010

Abstract excerpt

PURPOSE OF REVIEW: The review will integrate current knowledge of transcriptional circuits whose dysregulation leads to autoimmunity, neutropenia and leukemia. RECENT FINDINGS: Growth factor independent-1 (Gfi1) is a transcriptional repressor with essential roles in controlling hematopoietic stem cell biology, myeloid and lymphoid differentiation and lymphocyte effector functions. Recent work has suggested that...

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PMID: 20571393
DOI: 10.1097/moh.0b013e32833a06f8

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