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Article

Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature

5 Sept 2017

Abstract excerpt

Growth Factor Independence 1 (GFI1) is a transcriptional repressor that plays a critical role during both myeloid and lymphoid haematopoietic lineage commitment. Several studies have demonstrated the involvement of GFI1 in haematological malignancies and have suggested that low expression of GFI1 is a negative indicator of disease progression for both myelodysplastic syndromes (MDS) and acute myeloid leukaemia...

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PMID: 28894287
DOI: 10.1038/s41598-017-11718-8

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