Article
Characterization of a genomic region 8 kb downstream of GFI1B associated with myeloproliferative neoplasms.
Biochimica et biophysica acta. Molecular basis of disease - 1 Dec 2021
van Bergen Maaike G J M, van Oorschot Rinske, Bergevoet Saskia M, de Graaf Aniek O, Tönnissen Evelyn L R T M, Stevens-Linders Ellen, Neveling Kornelia, Jansen Pascal W T C, Baltissen Marijke P A, Vermeulen Michiel, Mandoli Amit, Martens Joost H A, Preijers Frank, Jansen Joop H, van der Reijden Bert A
Abstract excerpt
A genomic locus 8 kb downstream of the transcription factor GFI1B (Growth Factor Independence 1B) predisposes to clonal hematopoiesis and myeloproliferative neoplasms. One of the most significantly associated polymorphisms in this region is rs621940-G. GFI1B auto-represses GFI1B, and altered GFI1B expression contributes to myeloid neoplasms. We studied whether rs621940-G affects GFI1B expression and growth of...
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