Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription Factor GFI1B in Health and Disease

28 Mar 2017

Abstract excerpt

Many human diseases arise through dysregulation of genes that control key cell fate pathways. Transcription factors are major cell fate regulators frequently involved in cancer, particularly in leukemia. The GFI1B gene, coding a transcription factor, was identified by sequence homology with the oncogene GFI1 (Growth Factor Independence 1). Both GFI1 and GFI1B have six C-terminal C2H2 zinc-fingers and an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood disorders and treatments
Share to Erythrocyte Function and Pathophysiology
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28401061
DOI: 10.3389/fonc.2017.00054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription Factor GFI1B in Health and DiseasePMID 28401061Read ↗

Gfi-1 Oncoproteins in HematopoiesisSemantic proximity Read ↗

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formationSemantic proximity Read ↗

Gfi1–cells and circuits: unraveling transcriptional networks of development and diseaseSemantic proximity Read ↗

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.Semantic proximity Read ↗

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesisSemantic proximity Read ↗

Characterization of a genomic region 8 kb downstream of GFI1B associated with myeloproliferative neoplasms.Semantic proximity Read ↗

GFI1B mutation causes a bleeding disorder with abnormal platelet function.Semantic proximity Read ↗

Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cellsSemantic proximity Read ↗

The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune ResponsesSemantic proximity Read ↗

Gfi1 regulates miR-21 and miR-196b to control myelopoiesisSemantic proximity Read ↗

Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.