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Article

Gfi-1 Oncoproteins in Hematopoiesis

1 Oct 2003

Abstract excerpt

The family of Gfi-1 zinc finger transcriptional repressor oncoproteins consists of Gfi-1 and Gfi-1B. Recent gene targeting experiments and mutational screening in humans have revealed an essential role for Gfi-1 and Gfi-1B in hematopoiesis. Mice lacking Gfi-1 are unexpectedly neutropenic. Neutrophil differentiation is abolished and T lymphocyte differentiation is partially blocked in these mice. Heterozygous...

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PMID: 14530176
DOI: 10.1080/10245330310001612116

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