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Article

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis

14 Jun 2002

Abstract excerpt

In the search for genes expressed in hematopoietic stem cells, we identified that the expression of Gfi-1B (growth factor independence-1B) is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Gfi-1 and Gfi-1B are zinc finger proteins that share highly conserved SNAG and 6 zinc finger domains. Gfi-1 has been characterized as an oncogene involved in lymphoid malignancies in mice. In...

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PMID: 12351384
DOI: 10.1182/blood-2002-01-0182

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