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Article

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML

31 Dec 2012

Abstract excerpt

A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently, studies have shed light on developmental molecules and evolutionarily conserved signals as regulators of stem cells in hematopoiesis and leukemia. In this study,...

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PMID: 23277453
DOI: 10.1084/jem.20120596

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