Article

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

2021-07-16

Abstract excerpt

<h4>Summary paragraph</h4> Poly-(ADP-ribose) polymerase inhibitors (PARPi) elicit anti-tumour activity in homologous recombination defective cancers by promoting cytotoxic, chromatin-bound, “trapped” PARP1. How cells process trapped PARP1 remains unclear. By exploiting wild-type or trapping-resistant PARP1 transgenes combined with either a rapid immunoprecipitation mass-spectrometry of endogenous proteins (RIME)-...

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Literature Corpus work: 2d0ad440-34af-520c-b7af-f1c49d488d4f
DOI: 10.1101/2021.07.16.452473

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