bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)

Abstract excerpt

<h4>ABSTRACT</h4> Targeted degradation approaches have recently generated much excitement as a paradigm shift to address human disease in unprecedented ways. Amongst these, small molecule based approaches such as Proteolysis targeting chimeras (PROTACs) have attracted the lion’s share of attention due to their potential to tackle historically intractable targets and achieve greater potency, efficacy, and specific...

Topics

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• Acrylamides
• Agammaglobulinaemia Tyrosine Kinase
• Fluorescent Dyes
• Half-Life
• Intracellular Space
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

8607c349-a7d6-5412-83fe-1b60ee5abf99

DOI

10.1101/728071