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Article

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells.

Nature cell biology - 1 Feb 2021

Verma Priyanka, Zhou Yeqiao, Cao Zhendong, Deraska Peter V, Deb Moniher, Arai Eri, Li Weihua, Shao Yue, Puentes Laura, Li Yiwen, Patankar Sonali, Mach Robert H, Faryabi Robert B, Shi Junwei, Greenberg Roger A

Abstract excerpt

The response to poly(ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It remains unclear, however, if the established role of PARP in promoting chromatin accessibility impacts viability in these settings. Using a CRISPR-based screen, we identified the PAR-binding chromatin remodeller ALC1/CHD1L as a key...

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Identifiers

PMID: 33462394
DOI: 10.1038/s41556-020-00624-3
PMCID: PMC7880902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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