Article

A Population-Specific PARP1 Gene Variation Modulates PARP Trapping

2025-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Poly-(ADP-ribose) polymerase inhibitors (PARPi) block NAD + -binding pocket of PARP1, inhibiting PAR synthesis. However, they differ in their ability to retain PARP1 on damaged DNA to induce synthetic lethality in homologous recombination-deficient (HRD) cancer. Allosteric enzymatic activation requires destabilization of the helical domain (HD) of PARP1 and is indispensable for activation and c...

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Literature Corpus work: e21b4b93-b490-57bf-acc2-092c1ee01984
DOI: 10.1101/2025.11.11.687916

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