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Article

The complex universe of inactive PARP1.

Trends in genetics : TIG - 1 Dec 2024

Huang Doudou, Su Ziyi, Mei Yanxia, Shao Zhengping

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family, which modifies targets through ADP-ribosylation and plays key roles in a variety of biological processes. PARP inhibitors (PARPis) hinder ADP-ribosylation and lead to the retention of PARP1 at the DNA lesion (also known as trapping), which underlies their toxicity. However, inhibitors and mutations that make PARP1 inactive do not...

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PMID: 39306519
DOI: 10.1016/j.tig.2024.08.009

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