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Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader

18 Dec 2024

Abstract excerpt

Poly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells. Given that PARP1 inhibition can lead to synthetic lethality in cells with compromised homologous recombination, this enzyme has been identified as a potent target for anti-cancer therapeutics. However, the clinical application of existing PARP1...

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PMID: 39695097
DOI: 10.1038/s41419-024-07277-2

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