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Article

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes

8 Sept 2021

Abstract excerpt

The antitumor activity of poly(ADP-ribose) polymerase inhibitors (PARPis) has been ascribed to PARP trapping, which consists in tight DNA-protein complexes. Here we demonstrate that the cytotoxicity of talazoparib and olaparib results from DNA replication. To elucidate the repair of PARP1-DNA complexes associated with replication in human TK6 and chicken DT40 lymphoblastoid cells, we explored the role of Spartan...

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PMID: 34551432
DOI: 10.1093/nar/gkab777

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