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Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer Cells

2025-09-30

Abstract excerpt

Breast cancers are molecularly heterogeneous, with subtype-specific differences in transcriptional programs, chromatin architecture, and therapeutic responses. While PARP1 has been extensively studied in the context of DNA repair, emerging evidence implicates its catalytic activity in a broader set of cellular processes, including the regulation of gene expression. Here, we employed an NAD analog-sensitive PARP1 (...

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Literature Corpus work
76ace12a-a6ad-5b2a-9f27-71945399bb59
DOI
10.1101/2025.09.30.679484
Open publication

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Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer CellsDOI 10.1101/2025.09.30.679484
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