Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

1 Sept 2020

Abstract excerpt

DNA breaks recruit and activate PARP1/2, which deposit poly-ADP-ribose (PAR) to recruit XRCC1-Ligase3 and other repair factors to promote DNA repair. Clinical PARP inhibitors (PARPi) extend the lifetime of damage-induced PARP1/2 foci, referred to as 'trapping'. To understand the molecular nature of 'trapping' in cells, we employed quantitative live-cell imaging and fluorescence recovery after photo-bleaching....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32890402
DOI: 10.1093/nar/gkaa718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivoPMID 32890402Read ↗

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesionsSemantic proximity Read ↗

XRCC1 prevents toxic PARP1 trapping during DNA base excision repairSemantic proximity Read ↗

PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1Semantic proximity Read ↗

The complex universe of inactive PARP1.Semantic proximity Read ↗

ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modificationSemantic proximity Read ↗

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.Semantic proximity Read ↗

Molecular Imaging of PARPSemantic proximity Read ↗

A Population-Specific PARP1 Gene Variation Modulates PARP TrappingSemantic proximity Read ↗

A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activationSemantic proximity Read ↗

PARP1-specific inhibitor displays PARP1-detrapping activity.Semantic proximity Read ↗

CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependenciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.