Article

WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular deficits, and white matter damage, which are modified by humanized APOE alleles.

2025-10-09

Abstract excerpt

Vascular contributions are now widely accepted to play a key role in many cases of dementia, including Alzheimers disease (AD), that commonly manifest as cerebral small vessel diseases, including cerebral amyloid angiopathy (CAA). However, the mechanisms by which vascular contributions such as CAA contribute dementias such as AD are not well understood. This is due in part to the lack mouse models that develop rob...

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Literature Corpus work: 2ca500b2-66a1-5a7e-9c55-8c2a47f19a6a
DOI: 10.1101/2025.10.08.681261

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