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Article

Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2001

Winkler D T, Bondolfi L, Herzig M C, Jann L, Calhoun M E, Wiederhold K H, Tolnay M, Staufenbiel M, Jucker M

Abstract excerpt

A high risk factor for spontaneous and often fatal lobar hemorrhage is cerebral amyloid angiopathy (CAA). We now report that CAA in an amyloid precursor protein transgenic mouse model (APP23 mice) leads to a loss of vascular smooth muscle cells, aneurysmal vasodilatation, and in rare cases, vesse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Amyloid Angiopathy

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Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 11222652
PMCID: PMC6762950

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11222652-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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