Article
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
Nature neuroscience - 1 Sept 2004
Herzig Martin C, Winkler David T, Burgermeister Patrick, Pfeifer Michelle, Kohler Esther, Schmidt Stephen D, Danner Simone, Abramowski Dorothee, Stürchler-Pierrat Christine, Bürki Kurt, van Duinen Sjoerd G, Maat-Schieman Marion L C, Staufenbiel Matthias, Mathews Paul M, Jucker Mathias
Abstract excerpt
The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and dementia. In contrast to Alzheimer disease (AD), the brains of those affected by hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) show few parenchymal amyloid plaques. We found that neuronal overexpression of human E693Q APP in mice...
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