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Article

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease

2023-05-08

Abstract excerpt

The 5xFAD mouse model is a popular model of familial Alzheimer’s Disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the 5xFAD mouse has not been comprehensively phenotyped for vascular and metabolic perturbations over its lifespan. Male and female 5xFAD and WT littermates underwent in vivo 18 F-Fluorodeoxyglucose (FDG) positron emission tom...

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Identifiers and source

Literature Corpus work
108644bd-2bcf-5f24-b2df-4e7935d4c7be
DOI
10.1101/2023.05.05.539629
Open publication

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Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s diseaseDOI 10.1101/2023.05.05.539629
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