Article

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice

2020-07-22

Abstract excerpt

The deposition of amyloid β (Aβ) in blood vessels of the brain, known as cerebral amyloid angiopathy (CAA), is observed in more than 90% of Alzheimer’s disease (AD) patients. The presence of such CAA pathology is not as evident, however, in most mouse models of AD, thereby making it difficult to examine the contribution of CAA to the pathogenesis of AD. Since blood levels of soluble amyloid precursor protein (sAPP...

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Literature Corpus work: d98b60c9-1c80-5786-a4bf-856a3cd8548e
DOI: 10.1101/2020.07.22.215418

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