Article

Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites

2020-11-21

Abstract excerpt

The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions, which are reflected in its posttranslational modifications. We found that in human control brain, including the S. nigra , parkin is largely insoluble after age 40 years, which is linked to its oxidation, e.g., at Cys95 and Cys2...

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Literature Corpus work: 2c85b928-42b7-5b9e-9ba3-febf20efccbd
DOI: 10.1101/2020.11.20.392175

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