Stress-induced phospho-ubiquitin formation causes parkin degradation

Abstract excerpt

Mutations in the E3 ubiquitin ligase parkin are the most common known cause of autosomal recessive parkinsonism. Multiple types of stress decrease parkin protein levels, an effect that may be relevant to sporadic Parkinson's disease (PD), but the mechanism(s) involved in this loss remain largely unclear. We sought to elucidate these mechanisms using a PD-relevant stressor, L-DOPA, the precursor to dopamine, which...

Topics

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• Autophagy
• Mitochondria
• Neurodegenerative Diseases
• Oxidative Stress
• Parkinson Disease
• Protein Kinases
• Reactive Oxygen Species
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

63e41f07-2d6f-52d1-bbc0-1258626ac203

DOI

10.1101/484857