Article
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Yao Dongdong, Gu Zezong, Nakamura Tomohiro, Shi Zhong-Qing, Ma Yuliang, Gaston Benjamin, Palmer Lisa A, Rockenstein Edward M, Zhang Zhuohua, Masliah Eliezer, Uehara Takashi, Lipton Stuart A
Abstract excerpt
Many hereditary and sporadic neurodegenerative disorders are characterized by the accumulation of aberrant proteins. In sporadic Parkinson's disease, representing the most prevalent movement disorder, oxidative and nitrosative stress are believed to contribute to disease pathogenesis, but the exact molecular basis for protein aggregation remains unclear. In the case of autosomal recessive-juvenile Parkinsonism,...
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