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Article

Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways.

Neurobiology of disease - 1 Oct 2010

Saini Nidhi, Oelhafen Sandra, Hua Haiqing, Georgiev Oleg, Schaffner Walter, Büeler Hansruedi

Abstract excerpt

The mechanisms underlying neuron death in Parkinson's disease are unknown, but both genetic defects and environmental factors are implicated in its pathogenesis. Mutations in the parkin gene lead to autosomal recessive juvenile Parkinsonism (AR-JP). Here we report that compared to control flies,...

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Identifiers

PMID: 20483372
DOI: 10.1016/j.nbd.2010.05.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20483372-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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