Article
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
Human molecular genetics - 15 Dec 2005
Wang Cheng, Ko Han Seok, Thomas Bobby, Tsang Fai, Chew Katherine C M, Tay Shiam-Peng, Ho Michelle W L, Lim Tit-Meng, Soong Tuck-Wah, Pletnikova Olga, Troncoso Juan, Dawson Valina L, Dawson Ted M, Lim Kah-Leong
Abstract excerpt
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the development of the more common, sporadic form of Parkinson's disease (PD). Supporting this, we have recently demonstrated that parkin solubility in the human brain becomes altered with age. As parkin apparently functions as a...
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