Article

Oxidative stress-induced parkin misfolding, aggregation, and toxicity

2020-06-10

Abstract excerpt

<title>Abstract</title> <p>Background: Excess oxidative stress and protein misfolding are major hallmarks of neurodegenerative disease, including Parkinson’s disease (PD). Mutations in the genes encoding the ubiquitin ligase parkin cause autosomal recessive juvenile forms of Parkinsonism by the loss of parkin function in mitochondrial homeostasis and cellular protein quality control, generally. Dysfunction of par...

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Literature Corpus work: 87e0aeb7-b4a6-559d-a4d0-40294ac8658b
DOI: 10.21203/rs.3.rs-33898/v1

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