Article
S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.
Cell reports - 21 Nov 2017
Oh Chang-Ki, Sultan Abdullah, Platzer Joseph, Dolatabadi Nima, Soldner Frank, McClatchy Daniel B, Diedrich Jolene K, Yates John R, Ambasudhan Rajesh, Nakamura Tomohiro, Jaenisch Rudolf, Lipton Stuart A
Abstract excerpt
Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson's disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental factors causing a specific posttranslational modification on PINK1 can mimic these genetic mutations. We describe a molecular mechanism for impairment of...
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