Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effects of oxidative stress on parkin and other E3 ligases

17 Aug 2007

Abstract excerpt

Autosomal recessive mutations within the Parkin gene are associated with degeneration of the substantia nigra and locus coeruleus and an inherited form of Parkinson's disease (PD). As loss-of-function mutations in parkin are responsible for a familial variant of PD, conditions that affect wild-type parkin are likely to be associated with increased risk of idiopathic disease. Previous studies uncovered a unique...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cellular transport and secretion
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17883392
DOI: 10.1111/j.1471-4159.2007.04911.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effects of oxidative stress on parkin and other E3 ligasesPMID 17883392Read ↗

Oxidative stress-induced parkin misfolding, aggregation, and toxicitySemantic proximity Read ↗

Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine MetabolitesSemantic proximity Read ↗

Protein Misfolding and Aggregation in Parkinson's DiseaseSemantic proximity Read ↗

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.Semantic proximity Read ↗

Stress-induced phospho-ubiquitin formation causes parkin degradationSemantic proximity Read ↗

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.Semantic proximity Read ↗

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Semantic proximity Read ↗

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.Semantic proximity Read ↗

Post translational modification of ParkinSemantic proximity Read ↗

Pathologic and therapeutic implications for the cell biology of parkin.Semantic proximity Read ↗

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.Semantic proximity Read ↗

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.