Article

Zebrafish models of human-duplicated <i>SRGAP2</i> reveal novel functions in microglia and visual system development

2024-09-11

Abstract excerpt

The expansion of the human SRGAP2 family, resulting in a human-specific paralog SRGAP2C, likely contributed to altered evolutionary brain features. The introduction of SRGAP2C in mouse models is associated with changes in cortical neuronal migration, axon guidance, synaptogenesis, and sensory-task performance. Truncated SRGAP2C heterodimerizes with the full-length ancestral gene product SRGAP2A and antagonizes...

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Literature Corpus work: 81857cf4-7440-55a7-b7c7-5899476006d4
DOI: 10.1101/2024.09.11.612570

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