Article

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

2021-06-28

Abstract excerpt

The transposable elements (TEs) through evolutionary exaptation have become an integral part of human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While the functional impacts of TE-derived sequences on early embryogenesis are recognized, their role in malignancy has only started to emerge. Here we show that many TEs, especially the pluripotency-related endogenous retrovirus H...

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Literature Corpus work: 2c421e63-576a-5bbc-91dd-2d038f742498
DOI: 10.1101/2021.06.28.450127

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