Article

ARID2 loss destabilizes PBAF and drives colorectal cancer

2026-04-03

Abstract excerpt

The PBAF is one of three biochemically distinct BAF chromatin remodelers in humans. We previously proposed the role of ARID2, a PBAF component, as a bonafide tumor suppressor in colorectal cancer (CRC). Here, we validated loss of tumor suppression under conditions of ARID2 deficiency emanating from a marked reduction in PBAF complex assembly resulting from destabilization of PBAF-specific components BRD7, PHF10, a...

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Literature Corpus work: cc50ed50-bcee-5799-9fc2-c6322704076f
DOI: 10.64898/2026.04.01.715786

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