Article

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-driven transcription

2021-08-06

Abstract excerpt

<title>Abstract</title> <p>The transposable elements (TEs) through evolutionary exaptation have become an integral part of human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While the functional impacts of TE-derived sequences on early embryogenesis are recognized, their role in malignancy has only started to emerge. Here we show that many TEs, especially the pluripotency-rel...

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Literature Corpus work: c0b02837-dfcf-5610-a5cf-6e0df8b07e87
DOI: 10.21203/rs.3.rs-604974/v1

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