Article

Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression

2020-02-03

Abstract excerpt

Numerous genes are aberrantly expressed in tumors, but its cause remains unclear. Human endogenous retroviruses (HERVs) are repetitive elements in the genome and have a potential to work as enhancers modulating adjacent genes. Since numerous HERVs are activated epigenetically in tumors, their activation could alter gene expression globally in tumors and change the tumor characteristics. Here, we show the HERV acti...

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Literature Corpus work: e4b04b8a-671a-56be-9877-2177debe8e7b
DOI: 10.1101/2020.02.02.931501

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