Article

ecPath detects ecDNA in tumors from histopathology images

2024-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Circular extrachromosomal DNA (ecDNA) can drive tumor initiation, progression and resistance in some of the most aggressive cancers and is emerging as a promising anti-cancer target. However, detection currently requires costly whole-genome sequencing (WGS) or labor-intensive cytogenetic or FISH imaging, limiting its application in routine clinical diagnosis. To overcome this, we developed ecPa...

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Literature Corpus work: 8ed10af0-7508-5ffb-9345-0a667464c64d
DOI: 10.1101/2024.11.13.623494

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