Article

Onset of Mismatch Repair by the Human Mismatch Repair Protein, MutSbeta for a Biosensing Device

2024-02-02

Abstract excerpt

Deficiency of MutSbeta protein has been proven to be a cause of Lynch Syndrome, which leads to hereditary colorectal cancer. In the absence of MutSbeta, or the energy source to initiate the conformational change of MutSbeta, the DNA repair pathway would not detect the DNA base pairing errors resulting in a failure to proceed. To examine the essential role of MutSbeta and the interface between MutSbeta and a mismat...

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Literature Corpus work: 2c2f6bcb-e8d6-5d51-8ef0-0a3f7dd53f37
DOI: 10.1101/2024.01.31.578329

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