Article
Massively parallel single molecule tracking of sequence-dependent DNA mismatch repair <i>in vivo</i>
2023-01-08
Abstract excerpt
Whether due to mutagens or replication errors, DNA mismatches arise spontaneously in vivo . Unrepaired mismatches are sources of genetic variation and point mutations which can alter cellular phenotype and cause dysfunction, diseases, and cancer. To understand how diverse mismatches in various sequence contexts are recognized and repaired, we developed a high-throughput sequencing-based approach to track single m...
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Identifiers and source
- Literature Corpus work
- 2ce6a403-8c47-5181-956b-5270de7bf232
- DOI
- 10.1101/2023.01.08.523062