Article
Direct observation of three conformations of MutS protein regulated by adenine nucleotides.
Journal of molecular biology - 25 May 2001
Kato R, Kataoka M, Kamikubo H, Kuramitsu S
Abstract excerpt
Mismatched base-pairs, which are caused by either DNA replication errors, DNA damage or genetic recombination, are repaired by the mismatch-repair system. The MutS protein, a component of the mismatch-repair system, recognizes mismatched base-pairs in DNA, and its DNA-binding activity is affected by ATP and ADP. Here, we show that the MutS protein from Thermus thermophilus HB8 can have three different...
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