Article
The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.
Nature - 12 Oct 2000
Lamers M H, Perrakis A, Enzlin J H, Winterwerp H H, de Wind N, Sixma T K
Abstract excerpt
DNA mismatch repair ensures genomic integrity on DNA replication. Recognition of a DNA mismatch by a dimeric MutS protein initiates a cascade of reactions and results in repair of the newly synthesized strand; however, details of the molecular mechanism remain controversial. Here we present the crystal structure at 2.2 A of MutS from Escherichia coli bound to a G x T mismatch. The two MutS monomers have different...
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