Article
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.
Nucleic acids research - 22 Feb 2023
Bruekner Susanne R, Pieters Wietske, Fish Alexander, Liaci A Manuel, Scheffers Serge, Rayner Emily, Kaldenbach Daphne, Drost Lisa, Dekker Marleen, van Hees-Stuivenberg Sandrine, Delzenne-Goette Elly, de Konink Charlotte, Houlleberghs Hellen, Dubbink Hendrikus Jan, AlSaegh Abeer, de Wind Niels, Förster Friedrich, Te Riele Hein, Sixma Titia K
Abstract excerpt
The DNA mismatch repair protein MutSα recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation V63E in MSH2 that was found in the germline of a patient with suspected constitutional mismatch repair deficiency syndrome who developed colorectal cancer before the age of...
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