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Article

Mechanism of MutS searching for DNA mismatches and signaling repair.

The Journal of biological chemistry - 26 Dec 2008

Tessmer Ingrid, Yang Yong, Zhai Jie, Du Chungwei, Hsieh Peggy, Hingorani Manju M, Erie Dorothy A

Abstract excerpt

DNA mismatch repair is initiated by the recognition of mismatches by MutS proteins. The mechanism by which MutS searches for and recognizes mismatches and subsequently signals repair remains poorly understood. We used single-molecule analyses of atomic force microscopy images of MutS-DNA complexes, coupled with biochemical assays, to determine the distributions of conformational states, the DNA binding...

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Identifiers

PMID: 18854319
DOI: 10.1074/jbc.M805712200
PMCID: PMC2606009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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