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Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair

28 Jan 2021

Abstract excerpt

DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases in daughter strands. However, whether the MutS-MutL complex coordinates MMR by ATP-dependent sliding on DNA or protein-protein interactions between the mismatch and strand discrimination signal is ambiguous. Using functional MMR assays and systems preventing...

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PMID: 33510387
DOI: 10.1038/s41422-021-00468-y

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