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Dynamic human MutSα–MutLα complexes compact mismatched DNA

25 Jun 2020

Abstract excerpt

DNA mismatch repair (MMR) corrects errors that occur during DNA replication. In humans, mutations in the proteins MutSα and MutLα that initiate MMR cause Lynch syndrome, the most common hereditary cancer. MutSα surveilles the DNA, and upon recognition of a replication error it undergoes adenosine triphosphate-dependent conformational changes and recruits MutLα. Subsequently, proliferating cell nuclear antigen...

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PMID: 32586954
DOI: 10.1073/pnas.1918519117

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