Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The alternating ATPase domains of MutS control DNA mismatch repair.

The EMBO journal - 3 Feb 2003

Lamers Meindert H, Winterwerp Herrie H K, Sixma Titia K

Abstract excerpt

DNA mismatch repair is an essential safeguard of genomic integrity by removing base mispairings that may arise from DNA polymerase errors or from homologous recombination between DNA strands. In Escherichia coli, the MutS enzyme recognizes mismatches and initiates repair. MutS has an intrinsic ATPase activity crucial for its function, but which is poorly understood. We show here that within the MutS homodimer,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Adenosine Triphosphate
Share to Base Pair Mismatch

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Dimerization

Share to MutS DNA Mismatch-Binding Protein

Share to Nucleotides

Share to Vanadates

Source

Open in PubMed Open full text

Identifiers

PMID: 12554674
DOI: 10.1093/emboj/cdg064
PMCID: PMC140748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The alternating ATPase domains of MutS control DNA mismatch repair.PMID 12554674Read ↗

Mutations in the conserved glycine and serine of the MutS ABC signature motif affect nucleotide exchange, kinetics of sliding clamp release of mismatch and mismatch repair.Semantic proximity Read ↗

The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair.Semantic proximity Read ↗

Mechanism of MutS searching for DNA mismatches and signaling repair.Semantic proximity Read ↗

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.Semantic proximity Read ↗

Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repairSemantic proximity Read ↗

The MutS C terminus is essential for mismatch repair activity in vivo.Semantic proximity Read ↗

Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities.Semantic proximity Read ↗

Evidence for sequential action of two ATPase active sites in yeast Msh2-Msh6.Semantic proximity Read ↗

Requirement for Phe36 for DNA binding and mismatch repair by Escherichia coli MutS protein.Semantic proximity Read ↗

Identification and Characterization of a Thermostable MutS Homolog from Thermus aquaticusSemantic proximity Read ↗

Wot the 'L-Does MutL do?Semantic proximity Read ↗

Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.