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The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

2025-09-10

Abstract excerpt

<h4>Text Abstract</h4> Mobilization of long interspersed element-1 (LINE-1 or L1) compromises genome stability and can cause sporadic genetic disease. Accordingly, cells have evolved multiple mechanisms to restrict L1 retrotransposition. Several interferon-stimulated genes (ISGs) that interact with cytoplasmic L1 ribonucleoproteins (RNPs), which contain the L1-encoded proteins ORF1p and ORF2p, have been identifie...

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Literature Corpus work
2c2236da-b409-5612-afd3-00eaa11b84b3
DOI
10.1101/2025.09.09.675047
Open publication

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The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanismDOI 10.1101/2025.09.09.675047
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