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Article

STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation

18 Aug 2025

Abstract excerpt

The cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is known for its critical role in interferon and inflammatory responses. In addition, STING also has functions independent of interferon induction. In this study, we report that STING restricts the mobilization of the cellular retrotransposon long interspersed nuclear element 1 (LINE-1) independent of cGAS and interferon induction. LINE-1...

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PMID: 40825873
DOI: 10.1038/s44319-025-00551-0

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