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Article

RNA Sensor MDA5 Suppresses LINE-1 Retrotransposition By Regulating The Promoter Activity of LINE-1 5’-UTR

2021-02-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Type 1 long interspersed elements, or LINE-1, are the only active retroelements in human cells. The retrotransposition process of LINE-1 can trigger the activation of the innate immune system and has been proposed to play a role in the development of several autoimmune diseases, including Aicardi-Goutières syndrome (AGS). In contrast, all known AGS-associated pr...

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Literature Corpus work
94b76959-647a-5159-96c2-40d84cdbe150
DOI
10.21203/rs.3.rs-218045/v1
Open publication

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RNA Sensor MDA5 Suppresses LINE-1 Retrotransposition By Regulating The Promoter Activity of LINE-1 5’-UTRDOI 10.21203/rs.3.rs-218045/v1
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