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RNase L restricts the mobility of engineered retrotransposons in cultured human cells

25 Dec 2013

Abstract excerpt

Retrotransposons are mobile genetic elements, and their mobility can lead to genomic instability. Retrotransposon insertions are associated with a diverse range of sporadic diseases, including cancer. Thus, it is not a surprise that multiple host defense mechanisms suppress retrotransposition. The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is a mechanism for restricting viral infections during...

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PMID: 24371271
DOI: 10.1093/nar/gkt1308

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